A custom painting. It's better than a card full of cash.
A painting is a unique, memorable gift for any gift-giving occasion. Holidays, birthdays, weddings, retirements, bar mitzvahs, ransoms, heartfelt apologies... the list goes on. Hell, you can even gift a painting to yourself. You deserve it, probably.
Go off the registry.
Gift-shopping for a wedding? Sure, you can head to Bed Bath & Beyond and get them that toaster they requested. Or you can get them something truly unique and deeply meaningful, like a portrait painting.
Or a painting of a toaster.